We conducted a clinical effectiveness and safety of Loxoprofen sodium, a nonsteroidal antiinflammatory drug(NSAID) for the treatment of chronic low back pain. Loxoprofen sodiun 180 mg/day(60 mg three time daily) was administered to 30 patients
with
chronic low back pain associated with a range of arthritic disorders, for a period up to 4 weeks, and clinical efficacy was evaluated by objective and subjective methods. 4 weeks therapy, loxoprofen showed subjective improvements of 100%, 64.7%
and
63.6% in patients with mild to moderate, moderate to severe, and severe lumbar pain etc, respectively. Objective and subjective improvements were significant after only 1 week therapy in patients with mild to moderate pain and after 4 weeks,
over
all
intensities of pain were improved.
The incidence of adverse effects over this study population was extremely low, affecting only 3.3% of patients, and were mild in nature and edematous change.
Loxoprofen is thus a well-tolerated NSAID in the treatment of chronic lumbar pain.
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